Additional Resources and Assistance

CareASSIST is here to help you get the information and support you need. In addition to the program offerings, you may also find the following downloads and online resources helpful.

CareASSIST Downloads

CareASSIST Application Download

CareASSIST Application

The CareASSIST application covers all aspects of the program: Access and Reimbursement, Financial Assistance, and Resource Support. Follow the directions on the form to apply, or call 1-833-WE+CARE (1-833-930-2273) to get started.

CareASSIST Brochure Download

CareASSIST Brochure

The CareASSIST brochure contains an overview of the program and its offerings.

CareASSIST Copay Program Overview Brochure Download

CareASSIST Copay Program Overview Brochure

The CareASSIST Copay Program overview brochure describes the program and its requirements.

CareASSIST Resource Navigation Flashcard Download

CareASSIST Resource Navigation Flashcard

An overview of potential sources of prescription assistance.

Online Resources

Certain patients may require information or assistance beyond what CareASSIST may offer. Below are links to external organizations that may be able to help, or you can call 1-833-WE+CARE (1-833-930-2273) to learn about alternate coverage options.

Learn about Medicaid in your state and if you may be eligible.

Learn about Medicare and prescription drug coverage, eligibility, and how to access the care you may need.

Patient Advocate Foundation

Find help for insurance and healthcare access problems.

Patient Access Network Foundation

Offers help and hope to people with chronic or life-threatening illnesses for whom cost limits access to breakthrough medical treatments.

American Cancer Society

A nationwide, community-based voluntary health organization dedicated to eliminating cancer as a major health problem.

Cancer Support Community

A global network offering quality cancer support to millions of people touched by cancer, available online and at community-based centers and hospitals.

National Comprehensive Cancer Network®

A not-for-profit alliance of 28 leading cancer centers devoted to patient care, research, and education.


A leading national organization dedicated to providing free support services and financial assistance to anyone affected by cancer.


ZALTRAP® (ziv-aflibercept) is a prescription anti-cancer medicine used in combination with the chemotherapy regimen fluorouracil, leucovorin, and irinotecan-(FOLFIRI) to treat metastatic colorectal cancer that has progressed during or after treatment with other anti-cancer medicines that include oxaliplatin.


Patients treated with ZALTRAP have experienced serious side effects. Your doctor may adjust or stop your ZALTRAP treatment if you have these or other side effects:

  • Severe Bleeding (Hemorrhage). ZALTRAP can cause severe internal bleeding including bleeding of the digestive system, brain, or lungs. Signs and symptoms may include blood in the stool or urine, abdominal pain or lightheadedness.
  • Gastrointestinal Perforation. ZALTRAP can cause a hole in the stomach, esophagus, or intestines. Symptoms may include abdominal pain, vomiting, fever, and chills.
  • Wounds That Don’t Heal (Impaired Wound Healing). ZALTRAP can interfere with wound healing.
  • Do not undergo surgery or medical procedures (including tooth extractions) without discussing first with your doctors, as ZALTRAP should not be used at least 4 weeks before or 4 weeks after surgery and until the wound is fully healed.
  • A Fistula Could Form in Your Body. This is an abnormal passage that forms from one part of the body to another.
  • Hypertension (High Blood Pressure) may develop or get worse. In clinical trials, over half of patients treated with ZALTRAP who developed high blood pressure requiring treatment developed it within the first 2 cycles of ZALTRAP treatment. Your doctor will monitor your blood pressure regularly during treatment. Take anti-hypertensive therapy as directed by your doctor. Signs of high blood pressure may include severe headache, lightheadedness, confusion or similar neurological disorders.
  • Arterial Thromboembolic Events (Blood Clots That Form in Arteries). Blood clots can form and travel to the brain and cause a stroke; or to the heart and cause severe chest pain or other heart damage.
  • Too Much Protein in The Urine (Proteinuria). This may be a sign of kidney damage. Your doctor will monitor your urine protein levels during treatment. Signs of severe proteinuria may include swelling of the feet, hands, face, or abdomen.
  • Low White Blood Cell Count. This could lead to serious infections. Your doctor will monitor your white blood cell count regularly during treatment. Fever may be a sign of low white blood cell count and serious infection. Check your temperature regularly during treatment and tell your doctor if you have a fever.
  • Severe Diarrhea and Dehydration. Severe diarrhea can occur, especially in patients 65 years of age and older. Severe diarrhea (including vomiting) takes fluids from the body and can lead to dehydration.
  • RPLS (Reversible Posterior Leukoencephalopathy Syndrome). This is a very rare but serious brain disorder. Signs and symptoms include headache, seizures, visual changes and changes in mental function. These symptoms usually stop or improve within days, but some patients experienced continuing changes in mental function or death.
  • Embryo-Fetal Toxicity. If you are pregnant or plan to become pregnant, tell your doctor. ZALTRAP can harm your unborn baby. If you are able to become pregnant, use effective birth control with ZALTRAP and for 1 month following the last dose.

Before receiving ZALTRAP, tell your doctor if you:

  • have had bleeding problems, blood clotting problems, or are taking blood thinners (called warfarin [Coumadin®] or heparin) for the treatment of blood clots
  • are or have recently been coughing up blood
  • have gastrointestinal problems such as gastric ulcers or diverticulitis, or history of prior perforation of the intestine
  • have had a tooth extracted or any other surgery within the last 4 weeks, if you have a surgical wound that has not healed, or if you are going to have an operation or a dental or medical procedure
  • have high blood pressure
  • have heart or circulation problems, or history of stroke
  • have kidney problems
  • have history of seizures
  • are allergic to or have had a reaction to any medicine
  • had recent treatments for cancer that your doctor is not aware of
  • are pregnant or plan to become pregnant. ZALTRAP may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZALTRAP passes into your breast milk. Do not breastfeed while receiving ZALTRAP therapy and for one month following the last dose. If you are able to become pregnant, your doctor will give you a pregnancy test before you start treatment. Use effective birth control with ZALTRAP and for 1 month following the last dose.

The most common side effects of ZALTRAP include:

  • Low white blood cell count (leukopenia, neutropenia)
  • Diarrhea
  • Too much protein in the urine
  • Increase in liver enzymes
  • Painful sores in the mouth
  • Feeling tired and weak
  • Low blood platelet count. Tell your doctor if you have any unusual bruising or bleeding
  • Increased blood pressure
  • Weight loss
  • Decreased appetite
  • Nose bleed
  • Stomach (abdominal) pain
  • Change in voice (hoarseness)
  • Changes in kidney function
  • Headache

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of ZALTRAP. For more information, ask your doctor or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.